How do I clean and maintain a new Tempur-Pedic mattress?

Use a mattress protector to prevent stains and spills from reaching the mattress directly. Spot clean with mild soap and water for surface stains, and avoid soaking the material.
Rotating isn't necessary the way it is with spring mattresses, since the foam is engineered to resist sagging.

Not much maintenance is necessary with a Tempur-Pedic mattress. The only thing that's necessary is for you to lie down and sleep great every night.